|
KMID : 1150720170060040404
|
|
Integrative Medicine Research
2017 Volume.6 No. 4 p.404 ~ p.408
|
|
|
Carthami flos regulates gastrointestinal motility functions
|
|
Kim Ik-Sung
Bae Jin-Soo
Kim Byung-Joo
|
|
|
Abstract
|
|
|
Background: Gastrointestinal (GI) symptoms are common in the general population. This investigation studied the effects of Carthami flos (CF), a natural product, on GI motility.
Methods: We checked the intestinal transit rates (ITRs) or gastric emptying in normal and in GI-motility-dysfunction (GMD) mice in vivo. The GMD mice were made by acetic acid or streptozotocin.
Results: Both ITRs and gastric emptying were increased by CF (0.0025?0.25 g/kg) dose dependently. Also, in the GMD mice models, acetic-acid-induced peritoneal irritation, and streptozotocin-induced diabetic mice, the ITRs were decreased compared to normal mice, and these decreases were inhibited by CF.
Conclusion: These results suggest that CF is one of the good candidates for the development of a prokinetic agent that may regulate GI-motility functions.
|
|
|
KEYWORD
|
|
|
Carthami flos, Gastric emptying, Gastrointestinal motility, GI-motility dysfunction, Intestinal transit rate
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|